FACTORS CONTRIBUTING TO THE NEW CORONAVIRUS INFECTION, INCREASED RISK OF COMPLICATIONS AND DEATH FROM IT IN THE ARMED FORCES OF THE RUSSIAN FEDERATION

Based on the assessment of factors that contribute to a new coronavirus infection, the risk of complications, mortality, and lethality from it in the Armed Forces of the Russian Federation were analyzed. A detailed timeline of the development of the coronavirus pandemic in the Russian Federation has been demonstrated, showing indicators of peak and overall morbidity and mortality and prevailing strains of a new coronavirus infection, depending on the waves of the pandemic. The study evaluated the features of the course of a new coronavirus infection in the Eurasian region using data from the international register "Analysis of the dynamics of comorbid diseases in patients infected with severe acute respiratory syndrome-2 coronavirus”. Modern ideas about the main pathogenetic mechanisms of involvement of the circulatory system, which underlie the development of a severe course, mortality, and lethal outcomes, are outlined. The study also presented the concept of metabolic and hemodynamic insufficiency, which justifies the inability of the desynchronized circulatory system and systems of vascular homeostasis and hemostasis to restore the previous level of functioning after a new coronavirus infection. The possibilities of carrying out differentiated anti-epidemiological measures, including the use of information technologies, aimed at reducing the spread of a new coronavirus infection, were evaluated. The mortality and mortality from a new coronavirus infection in the Armed Forces of the Russian Federation, including the effect of a new coronavirus infection on an increase in the incidence of non-communicable diseases in military personnel of different age groups, were presented. The study also considered issues of the need to introduce a rehabilitation strategy to correct conditions that occur after a new coronavirus infection, reduce the risk of subsequent mortality and lethality, and reduce it in the long term. All rights reserved © Eco-Vector, 2022.

Differentiated approach to the implementation of preventive and anti-epidemic measures among military personnel based on the COVID-19 disease risk assessment scale

Aim of the study - to develop a scale for assessing the risk of COVID-19 disease for a differentiated approach in conducting preventive and anti-epidemic measures among military personnel. Material and methods. An array of published data was analyzed to select the risk factors for a possible COVID-19 disease. The disease risk assessment scale proposed on the basis of this analysis is implemented in the form of a table in MS Excel and a program in MS Visual Studio in C# with the inclusion of recommendations for making a management decision. Results. The risk factors for COVID-19 disease were selected and included in the questionnaire. A scale for assessing the risk of COVID-19 disease was developed: when a risk factor was identified, one point was assigned;otherwise, zero points were assigned. Then all the points are added together, and this amount is considered proportional to the risk of contracting COVID-19. The resulting total score is correlated with the recommendations for the scope of preventive and anti-epidemic measures. With the program implementation of the scale, it is possible to quickly make an adequate management decision. Conclusion. The use of such approaches can be a significant contribution to the fight against the new coronavirus infection.Copyright © 2021 Infectious Diseases: News, Opinions, Training. All rights reserved.

Mechanisms of Damage to the Cardiovascular System in COVID-19

The review article is devoted to the analysis of the literature on the various mechanisms of damage to the cardiovascular system in COVID-19. The article briefly outlines the epidemiology and urgency of the COVID-19 problem, describes the features of the clinical picture of heart muscle damage in COVID-19. The pathophysiology, morphology and pathogenetic mechanisms of myocardial involvement in cases of SARS-CoV-2 lesion are considered in detail. The authors present a diagram of various mechanisms of myocardial damage in COVID-19, which includes mediated damage to the heart muscle through angiotensin-converting enzyme 2, myocardial damage caused by hypoxemia, microvascular heart damage, and systemic inflammatory response syndrome. A detailed scheme of cardiomyocyte infection with the involvement of cytokines, which ultimately leads to myocardial remodeling and dilated cardiomyopathy, is presented. The pathophysiological foundations of the development of sudden cardiac death in COVID-19, which include the mechanisms of life-threatening arrhythmias, acute coronary syndrome, and heart failure, are considered. The authors analyzed scientific studies of the toxic effects of COVID-19 drug treatment on the heart muscle, in particular, antiviral, antibacterial, antimalarial agents. Their potential benefits and harms, as well as the likelihood of developing cardiovascular events, in particular sudden cardiac death, were assessed. © 2021 Izdatel'stvo Meditsina. All rights reserved.

Differentiated approach to the implementation of preventive and anti-epidemic measures among military personnel based on the COVID-19 disease risk assessment scale

Aim of the study - to develop a scale for assessing the risk of COVID-19 disease for a differentiated approach in conducting preventive and anti-epidemic measures among military personnel. Material and methods. An array of published data was analyzed to select the risk factors for a possible COVID-19 disease. The disease risk assessment scale proposed on the basis of this analysis is implemented in the form of a table in MS Excel and a program in MS Visual Studio in C# with the inclusion of recommendations for making a management decision. Results. The risk factors for COVID-19 disease were selected and included in the questionnaire. A scale for assessing the risk of COVID-19 disease was developed: when a risk factor was identified, one point was assigned;otherwise, zero points were assigned. Then all the points are added together, and this amount is considered proportional to the risk of contracting COVID-19. The resulting total score is correlated with the recommendations for the scope of preventive and anti-epidemic measures. With the program implementation of the scale, it is possible to quickly make an adequate management decision. Conclusion. The use of such approaches can be a significant contribution to the fight against the new coronavirus infection. © 2021 Infectious Diseases: News, Opinions, Training. All rights reserved.